Further, in combination with lifestyle and diet, this drug showed greater weight loss as compared to placebo [2]
Digestive issues: Constipation or diarrhea may occur in some patients
The physiological mechanisms driving weight regain after semaglutide cessation are multifactorial
This could relate to different pharmacokinetic profiles, lower peak drug levels, or differences in how the oral versus injectable forms interact with the nervous system
Osteoarthritis is also biologically heterogeneous, involving cartilage, bone, synovium, nerves, and systemic metabolic factors rather than a single disease pathway. Mandelbaum said there are lifestyle factors people can adopt to help lower the risk of osteoarthritis as well as its painful effects